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Description: Here is a brown hair is seen under the microscope using transmission light microscopy. Here is a brown hair is seen under the microscope using polarized light microscopy.
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Description: Polarization modulation and synchronous detection along with Mueller calculus were used to analyze the degrees of surviving circular and linear polarization as well as optical rotation from turbid samples. The preservation of circular polarization was found to exceed the preservation of linear polarization for all samples examined. The optical rotation induced by the samples increased with chiral molecule concentration only (glucose). These results demonstrate the potential for polarized light based glucose monitoring in multiply scattering media.
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Description: Chronic total occlusions of coronary and peripheral arteries are defined as arteries that appear occluded under angiography and are thought to have been present for greater than one month. Current intravascular interventions are limited by the lack of a suitable guidance means for differentiating between the occluded lumen and the vessel wall. Optical Coherence Tomography (OCT) is an attractive means for providing depth-resolved guidance during intervention of these lesions due to its sensitivity to the different arterial components. Previous work sought to evaluate OCT's ability to image different pathologies seen in CTOs using a time domain system to image arterial segments. Here we explore the use of a miniaturized electrothermal polymer incorporated into a catheter with a GRIN lens as a means of providing an intravascular image. Imaging parameters of the probe will be discussed. The appearance of tapered entrances of CTOs is presented. The use of a swept-source frequency domain imaging system is shown to provide greater imaging range through clarified endoluminal microchannels; doppler flow through these channels is also seen which may aid in guidance during recanalization.
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Description: Four slides which are part of a larger presentation to be displayed at an info booth. The slides describe optical property changes in Laser Interstitial Thermal Therapy of solid tumors. As the laser light heats and coagulates tissue the optical properties change, making treatment planning difficult, but also offering an opportunity for monitoring. The benefits of optical monitoring over temperature measurement are outlined.
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Description: Bright Field Illumination Kingdom: Animalia Phylum: Rotifera Bdelloid rotifer Organism commonly found in fresh water. Common in ponds and on mosses, are soft-bodied, and have leech-like movements. In the picture the corona is retracted. Note the projected structure, called rostrum, with bright red eyes. Dark Field Illumination Kingdom: Animalia Phylum: Rotifera Bdelloid rotifer Organism commonly found in fresh water. Common in ponds and on mosses, are soft-bodied, and have leech-like movements. In the picture the corona is retracted. Note the projected structure, called rostrum, with bright red eyes.
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Description: The eye is made up of different structures that allow it to receive light from the different objects that form our world. Detectors at the back of the eye (retina) sense the light and convert it into an electrical signal which is sent to the brain. The brain interprets the different colors and intensities of lights and puts them together as an image.
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Description: Interstitial laser photo coagulation is a promising treatment modality that utilizes an optically-induced temperature rise to thermally destroy tumors. One of the challenges of this therapy is its dynamic nature, as tissue properties (optical, thermal, blood flow, etc) change during therapy, hence making pre-treatment planning very challenging. This added complexity necessitates the use of real-time, on-line feedback. Here, we propose the use of interstitial optical fiber sensors for this purpose, and describe a methodology for determining their in-situ position. This should ensure high-quality feedback data for ILP treatment optimization.
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Description: The wide variety of diagnostic and therapeutic applications of optical, thermal, and radiation biophysics in today's medical practice are discussed in this course. The physical and biophysical interaction mechanisms between the energy sources and tissue are emphasized. Fundamentals of optical, thermal, and radiation dosimetry are covered, with reference to the relevant tissue properties, the models of energy propagation within tissues, experimental techniques for dosimetry measurements, and the resulting biological effects. This sets the stage for discussing selected clinical and investigational uses of light, heat, x-rays, microwaves, and ultrasound. Examples include radiation therapy, x-ray and optical mammography, fluorescence imaging and spectroscopy, optical coherence tomography, photodynamic therapy, biological confocal microscopy, laser-, microwave-, and ultrasound-induced thermal therapies, and Raman spectroscopy.
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Description: Photodynamic therapy (PDT) is novel treatment option for recurrent prostate cancer. Although this technique appears to be promising, several challenges remain in quantifying the tissue response to treatment, such as vascular response. Monitoring and quantifying this biological response in real-time may provide early assessment of treatment efficacy. An exciting and unique approach to image and quantify the PDT-induced vascular response is Doppler optical coherence tomography (DOCT). DOCT exhibits micron-scale spatial resolution allowing visualization of structures at near-cellular-levels, and yields flow velocity resolution of ~100 µm/s (in vivo). Needle based IS-DOCT is an attractive approach for deep in vivo tissue assessment. An interstitial (IS) needle probe (22 gauge, OD=0.7mm) was developed for minimally invasive monitoring of the microvascular response to PDT deep within tumor tissue. Rats were administered a light sensitizing drug, Photofrin, and 20-24 h later the tumours were irradiated superficially at 635nm with irradiance rates of 13-180 mW/cm2 for 25 minutes, to total light doses of 25-200 J/cm2. Results demonstrate different rates of vascular shutdown within the tumor, depending on PDT irradiance rate and light dose. Controls (needle + light, needle only) showed no significant microvascular changes. Three dimensional high frequency ultrasound imaging was also performed to confirm IS-DOCT needle placement and image gross tissue architecture. Microvascular shutdown occurred at different rates and correlated with PDT light dose and irradiance rate. These dependencies may play an important role in pre-treatment planning, feedback control for treatment optimization, and post PDT treatment assessment. Although this study’s primary goal was improving the ability to monitor and quantify PDT in prostate cancer, the techniques developed here can be applied to PDT of other solid organs, and for real-time monitoring of other vascularly targeted cancer treatments (i.e. anti-angiogenic chemotherapy)
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Description: Doppler OCT (DOCT) can perform fast imaging of structural and functional parameters of tissue, at near-microscopic resolution and with perfusion-level blood flow sensitivity. In this example, we use a time-domain DOCT system to image the beating 3-chamber heart of the tadpole, and display the resultant structural-only OCT information (for corresponding Doppler images, see movie 2, same album). DOCT's ability to perform fast structural and Doppler imaging will be important for developmental biology, early disease detection, and treatment monitoring studies.
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Description: Myocardial infarction leads to remodeling of the myocardium, resulting in a deterioration of cardiac function. This remodeling involves changes in the collagen content and organization in the myocardium. Recently developed stem-cell based regenerative treatments have been shown to reduce myocardial remodeling and collagen formation after infarction, however, this emerging field is in dire need of biomarkers to monitor these treatments. Because collagen fibers exhibit birefringence there is the possibility of using polarized light for treatment monitoring. This is explored through experimental measurements and Monte Carlo calculations to demonstrate the potential for polarized light based monitoring of these regenerative treatments.
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Description: Doppler OCT can perform fast imaging of structural and functional parameters of tissue, at near-microscopic resolution and with perfusion-level blood flow sensitivity. In this example, we use a time-domain DOCT system to image the blood flow dynamics in the vessels leading to the heart of a developing African clawed frog tadpole (Xenopus Laevis). DOCT's ability to image and quantify blood flow dynamics will be important for developmental biology, early disease detection, and treatment monitoring studies. For corresponding structural images, see movie 1, same album.
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Description: Probe placement in vertebral body- axial plane
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FDA grants Fast Track Designation to Celsion's ThermoDox for liver cancer treamtment
NIH announces award to improve human microbiome research
DUSA Pharmaceuticals to Present at the Rodman & Renshaw 12th Annual Healthcare Conference
PROGRAM OPERATIONS SPECIALIST (TEMPORARY) - Seattle, WA
Tenured/Tenure Track Faculty Position - Nashville, TN
LATIN AMERICA OPTICS AND PHOTONICS CONFERENCE (...
International Optoelectronics Exhibition 2010 (...
16th Microoptics Conference (MOC'10)
