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Profile for Frank Y. S. Chuang

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Researcher

fchuang@ucdavis.edu

Frank Y. S. Chuang, M.D., Ph.D. is a medical scientist at UC Davis Medical Center in Sacramento and an Associate Director of the NSF Center for Biophotonics, Science and Technology (CBST). After receiving his undergraduate degree in bioengineering at the University of California, Berkeley in 1987, Frank joined a team of clinical researchers at Lawrence Berkeley National Laboratory (LBNL) to develop one of the first systems to treat surgically-inoperable brain tumors using accelerated heavy charged-particle beams. This work was done in collaboration with UC San Francisco and Stanford University Medical Centers, and led to the eventual construction of the dedicated medical proton accelerator facility at Loma Linda Medical Center. In 1990, Frank received a fellowship from the National Institutes of Health (NIH) to join the Medical Scientist Training Program (MSTP) at the Mount Sinai School of Medicine in New York. His graduate research using fluorescence microscopy and spectroscopy to characterize the transmembrane signal activation of human white blood cells contributed to the current body of evidence which supports the existence of lipid “rafts” and microdomains in biomembrane architecture and physiology.

After completing his medical training and receiving a Ph.D. in immunology and biophysics, Dr. Chuang returned to California as a post-doctoral research fellow at the Lawrence Livermore National Laboratory (LLNL). In the Division of Medical Physics and Biophysics (M-Division, formerly the Medical Technology Program), he was the lead biomedical scientist for several projects developing new in vitro diagnostic systems for rapid, multiplex detection of microbial pathogens, and has written numerous papers and book chapters on optical methods of biodetection. Dr. Chuang serves as an executive (helping to manage ~30 research projects currently supported by CBST), educator (developing curricula and teaching workshops in select biophotonic topics) and researcher (focusing on optical tissue imaging and development of advanced nanoparticles). Dr. Chuang also works in part for the LLNL-UC Davis Integrated Cancer Center and is leading the effort to develop clinical applications for a revolutionary new compact proton accelerator being designed and built at Lawrence Livermore Lab.

Frank 's organizations

Frank 's home page

http://cbst.ucdavis.edu/people/fchuang

Academic distinctions, awards

1987 Graduated with Honors, University of California at Berkeley, College of Engineering
1987 Bechtel Foundation Engineering Award and Scholarship
1987 Tau Beta Pi National Engineering Honor Society
1990 NIH Medical Scientist Training Program fellowship, Mount Sinai School of Medicine, NY
2000 Clinical Clerkship Honors in Emergency Medicine, Senior Pediatrics and Anesthesiology – Mount Sinai School of Medicine, New York, NY

Selected publications

Dougherty GM, Rose KA, Tok JBH, Pannu SS, Chuang FYS, Sha MY, Chakarova G, Penn SG; The zeta potential of surface-functionalized metallic nanorod particles in aqueous solution. Electrophoresis, 29(5): pp. 1131-1139: 2008
Tok JBH, Chuang FYS, Kao MC, Rose KA, Pannu SS, Sha MY, Chakarova G, Penn SG, Dougherty GM; Metallic striped nanowires as multiplexed immunoassay platforms for pathogen detection. Angewandte Chemie(International ed 45, 6900-6904 (2006).
Bates TW, Paulson C, Kostova, T, Chuang FYS, Chang J, Descalle M, Bagheri N, Estacio P, Colston B, Milanovich F; A system for continuous monitoring of person-to-person contact, with reference to utilization in public health investigations. Computer Methods and Programs in Biomedicine 2003. Also available as Lawrence Livermore National Laboratory Technical Report UCRL-152342
Chuang FYS, Sassaroli M, Unkeless J: Convergence of Fc-gamma Receptor IIA and Fc-gamma Receptor IIIB Signaling Pathways in Human Neutrophils. J. Immunology, 164: 350-360: 2000.
Fein M, Unkeless J, Chuang FYS, Sassaroli M, DaCosta R, Väänänen H, Eisinger J: Lateral Mobility of Lipid Analogues and GPI-Anchored Proteins in Supported Bilayers Determined by Fluorescent Bead Tracking. J. Membrane Biol., 135: 83-92: 1993.
Matthews DL, Alvis R, Boggan J, Chuang FYS, et al. Overview of Research Activities at the NSF Center for Biophotonics Science and Technology. In Wilson BC et al. (Eds): Advances in Biophotonics, NATO Science Series I: Life and Behavioural Sciences – Vol. 369. IOS Press, Amsterdam, Netherlands, pp. 267-282: 2005.
Chuang FYS, Colston BW. Rapid, Multiplex Optical Biodetection for Point-of-Care Applications. In Narayanaswamy et al. (Eds): Optical Sensors for Industrial and Environmental Applications, Springer-Verlag Heidelberg, Germany 2003
Frankel KA, Phillips MH, Lyman JT, Chuang FYS, Fabrikant JI, Levy RP, Rosander K. Treatment planning for stereotactic heavy-charged-particle radiosurgery of the brain. In Steiner L et al. (Eds): Radiosurgery: Baseline and Trends, Raven Press, Ltd., New York, pp. 75-83: 1992.
Levy RP, Fabrikant JI, Frankel KA, Phillips MH, Steinberg GK, Marks MP, DeLaPaz RL, Chuang FYS. Clinical-radiological evaluation of sequelae of stereotactic radiosurgery for intracranial arteriovenous malformations. In Steiner L et al. (Eds): Radiosurgery: Baseline and Trends, Raven Press, Ltd., New York, pp. 209-220: 1992.

This personal profile was last updated over 3 years ago



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