The focus of my laboratory is to investigate minimally invasive novel optical methods for cancer detection and therapy using biophotonics and nanotechnology.
The novel optical methods being investigated are Surface Enhanced Raman Spectroscopy and Imaging (SERS) for biosensing and bioimaging; SERS spectroscopy and imaging with nanophotonics is being investigated for protein and biomarker sensing and tracking in cells and tissues both in-vivo and in vitro. Endoscopic catheter based in vivo cellular imaging systems using in-vivo multiphoton confocal microscopy, Optical Coherence Tomography (OCT) and photothermal imaging are combined with novel bio-chemo-synthetic optical probes and their formulations. These novel optical methods are compared with currently used fluorescence and autofluorescence detection methods in translational medicine. Our major objective is to devise optical on-line real time imaging and therapeutic systems. We are also using image processing software and endomicroscopic approaches to develop an optical biopsy technique to stage cancer. Our ex-vivo methods in fluorescence based cytology of biofluids combines the use of multiphoton confocal microscopy and fluorescence life-time imaging to stage cancer histopathologically. This may prove to be a superior method to the current widely used gold standards i.e white light endoscopy and histopathology.
The laboratory is also investigating the treatment of head and neck, and bladder cancers using novel formulations of photosensitizer and optical imaging technologies.
This personal profile was last updated over 2 years ago