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Transforming Biomedicine at the Interface of the Life and Physical Sciences (R01)

NIH (NIBIB, NIGMS, NIAMS), NSF
Application deadline: 2012-05-18
LOI deadline: 2012-04-18

http://grants.nih.gov/grants/guide/pa-files/PAR-10-141.html

The National Institutes of Health and the National Science Foundation are issuing this joint announcement to encourage grant applications from institutions/organizations to encourage quantitative/physical scientists and engineers to apply their unique skills and perspectives to overcome important problems in translational research and catalyze clinical advances.

Some of the most significant biomedical advances in recent decades have emerged from the interface of the life and physical sciences, such as MR imaging, multifunctional biomarkers, drug-eluting stents, orthopedic devices, cochlear implants, pacemakers, high-throughput screening, cell-based therapies, and minimally-invasive procedures. Such advances have had a profound impact on health and the quality of life, and were driven by critical collaborations with scientists trained in the physical and quantitative fields. It is the intermingling of approaches from one area, applied to problems of another, that makes research at the intersection of the life and physical sciences so rich and full of opportunities (Research at the Intersection of the Physical and Life Sciences, National Research Council, National Academies, November 2009). Scientific contributions involving advanced computation and mathematics, optics, automation, process control, chemical and material engineering, optimization, and microelectronics are just a few of the disciplines and research areas that have underpinned many biomedical advances. This announcement encourages investigators from these disciplines and other research areas to partner with clinical researchers to translate promising laboratory concepts into the clinic.

Projects must propose an innovative application of the physical or quantitative sciences to help solve a translational or clinical problem. The application must highlight why a bridging approach is necessary and how this will lead to clinical implementation. It is strongly recommended that the project have at least one PD/PI from the physical or quantitative sciences, and at least one PD/PI from the clinical/biomedical sciences. To help ensure ultimate clinical utility, it is also recommended that these projects involve a commercial partner. Their role can vary from consultancy, active engagement in project design, to a substantial investment of project resources. It is expected that projects with greater or increasing levels of commercial involvement are more likely to achieve successful translation.

Illustrative examples of potential topics include, but are not limited to:

  • Deep Imaging Technologies – Develop whole-tissue, three-dimensional imaging with sub-micron resolution for studying tissue and cellular connectivity, metabolism and dynamics.
  • Develop computational models and/or informatics tools to analyze connectivity of cellular regulatory pathways, signal transduction pathways, and other biological processes.
  • Health Cyberinfrastructure – Adapt and create technologies for data integration, sharing and mining across disparate platforms for research, clinical decision support, and electronic health records.
  • Development of Biomarkers and Related Platform Technologies & Methods for Drug Discovery, Delivery and Response – Leverage ongoing efforts to develop and validate molecular biomarkers for many conditions, stimulate radically new platform technologies for data collection, and develop computational models to simulate biomarker response to therapy.
  • Quantitative and Personalized Image-Guided Interventions (IGI) – Integrate the fields of IGI and molecular biology to develop personalized IGI with tailored applications for the treatment of cancer, cardiovascular and neurological diseases. Develop computational strategies to radiation treatment that can be individualized and to minimize unnecessary radiation exposure.
  • Improved Biomaterials – Develop biomaterials that integrate with tissue to form chronically-stable capsule-free biotic-abiotic interfaces; complex scaffold materials to promote 3-dimensional tissue regeneration.

NIBIB, NIGMS and NSF will consider a broad spectrum of research at the interface of the life and physical sciences, consistent with their missions. To be considered for funding by the NIAMS, applications must align with its mission of reducing the burden of arthritis and musculoskeletal and skin diseases. Applications most appropriate for NIAMS funding will propose research in basic biology, translational study and diseases of the muscles, skin, joints and bone. These applications should have the potential of advancing our understanding of diseases or improving human conditions or leading to prevention or novel therapies of diseases in NIAMS mission.

Letters of Intent Receipt Date(s): April 18, 2010; April 18, 2011; April 18, 2012
NOTE: On-time submission requires that applications be successfully submitted to Grants.gov no later than 5:00 p.m. local time (of the applicant institution/organization).
Application Due Date(s): May 18, 2010; May 18, 2011; May 18, 2012

New Biomedical Frontiers at the Interface of the Life and Physical Sciences (R01)

NIH (NIBIB, NIGMS, NIAMS) & NSF
Application deadline: 2012-05-18
LOI deadline: 2012-04-18

http://grants.nih.gov/grants/guide/pa-files/PAR-10-142.html

Research objectives

A number of innovative techniques and discoveries developed in the physical, computational and engineering sciences have resulted in tremendous breakthroughs in the biological and life sciences. In many cases, important biomedical problems could not have been solved without the critical involvement of engineers and physicists, such as the development of new imaging technologies, nanotechnology, and high throughput screening technologies. It is the intermingling of approaches from one area, applied to problems of another, that makes research at the intersection of the life and physical sciences so rich and full of opportunities (Research at the Intersection of the Physical and Life Sciences, National Research Council, National Academies, November 2009). The purpose of this initiative is to provide support for cutting-edge, visionary research, only possible through bridging the sciences, with the goal of setting the stage for the next biomedical breakthrough.

The National Institutes of Health and the National Science Foundation are issuing this joint announcement to encourage grant applications from institutions/organizations that propose discovery research that may create entirely new areas of biomedical investigation through bridging the physical and life/behavioral sciences. Appropriate topics include, but are not limited to those listed below:

  • self-healing/replicating nanodevices
  • biological computing
  • biologically-inspired next generation materials
  • biological power sources
  • non-invasive identification of disease
  • modeling and real-time observation of biomolecular and pharmacologic interactions: in vivo, in vitro, in silico
  • theoretical models of intercellular processes and robust methods for manipulation
  • accurate prediction of electrostatic interactions, solvent effects in aqueous biological systems, and trajectories of reactions
  • adapt complex methodologies, such as dynamical systems analysis, agent based modeling, discrete event simulation, and network analysis to problems such as quorum sensing, interconnected networks of cellular regulatory pathways, signal transduction, and social interactions and behavior change

NIBIB, NIGMS and NSF will consider a broad spectrum of research at the interface of the life and physical sciences, consistent with their missions. To be considered for funding by the NIAMS, applications must align with its mission of reducing the burden of arthritis and musculoskeletal and skin diseases. Applications most appropriate for NIAMS funding will propose research in basic biology, translational study and diseases of the muscles, skin, joints and bone. These applications should have the potential of advancing our understanding of diseases or improving human conditions or leading to prevention or novel therapies of diseases in NIAMS mission.

This initiative is forward-looking, so biomedical translation of the research need not be apparent at the time of application. Awards will be based on the degree of innovation and extent of potential paradigm shift – whether in an existing area or in the creation of an entirely new one. Approaches to overcome exceedingly difficult technical problems, even where prior attempts have failed, are welcome if the proposed technology or approach offers revolutionary new capabilities. This announcement supports a broad range of high-risk, biomedical research that can only be accomplished by bridging the physical, computational or engineering with the life and/or behavioral sciences. It is expected that there will be meaningful intellectual and project leadership contributions from multiple disciplines, so applications are strongly encouraged with multiple PIs that represent the physical, computational or engineering, and life and/or behavioral sciences. As this initiative is meant to underpin innovative new approaches, New Investigators that can contribute highly inventive perspectives are encouraged to apply. This bridging research should focus on developing enabling capabilities that can have future biomedical impact, and not on the immediate needs. Funded projects are expected to catalyze and generate new approaches and fields of biomedical study that can only emerge from the interface of the sciences.

Letters of Intent Receipt Date(s): April 18, 2010; April 18, 2011; April 18, 2012
NOTE: On-time submission requires that applications be successfully submitted to Grants.gov no later than 5:00 p.m. local time (of the applicant institution/organization).
Application Due Date(s): May 18, 2010; May 18, 2011; May 18, 2012

Academic-Industrial Partnerships for Translation of in vivo Imaging Systems for Cancer Investigations (R01)

NIH, NCI
Application deadline: 2012-06-05

This Funding Opportunity Announcement (FOA) issued by the Cancer Imaging and Radiation Research Programs of the National Cancer Institute (NCI), National Institutes of Health (NIH), encourages applications from research partnerships formed by academic and industrial investigators to accelerate the translation of either animal or human in vivo imaging, image guided, and/or spectroscopic systems and methods designed to solve targeted cancer problems for cancer research, clinical trials, and/or clinical practice. The partners on each application will establish an inter-disciplinary, multi-institutional research team to work in a strategic alliance to implement a coherent strategy to develop and translate the proposed system or methods with potential for significant impact on preclinical, single, or multisite clinical studies. Partnerships must include at least one lead academic and one lead industrial organization large or small among their numbers. For either preclinical or clinical research, funding may be requested for limited additional copies of prototype systems and methods in order to optimize and validate them across different platforms and/or research sites. Each partnership is encouraged to plan to solve its choice of targeted cancer problem within the five year funding period. This FOA supports clinical trials that emphasize optimization and validation of the performance of imaging systems, including devices, agents and/or methods. It will not support commercial production.

Academic-Industrial Partnerships for Translation of in vivo Imaging Systems for Cancer Investigations (R01)

NIH, NCI
Application deadline: 2012-10-05

This Funding Opportunity Announcement (FOA) issued by the Cancer Imaging and Radiation Research Programs of the National Cancer Institute (NCI), National Institutes of Health (NIH), encourages applications from research partnerships formed by academic and industrial investigators to accelerate the translation of either animal or human in vivo imaging, image guided, and/or spectroscopic systems and methods designed to solve targeted cancer problems for cancer research, clinical trials, and/or clinical practice. The partners on each application will establish an inter-disciplinary, multi-institutional research team to work in a strategic alliance to implement a coherent strategy to develop and translate the proposed system or methods with potential for significant impact on preclinical, single, or multisite clinical studies. Partnerships must include at least one lead academic and one lead industrial organization large or small among their numbers. For either preclinical or clinical research, funding may be requested for limited additional copies of prototype systems and methods in order to optimize and validate them across different platforms and/or research sites. Each partnership is encouraged to plan to solve its choice of targeted cancer problem within the five year funding period. This FOA supports clinical trials that emphasize optimization and validation of the performance of imaging systems, including devices, agents and/or methods. It will not support commercial production.

Academic-Industrial Partnerships for Translation of in vivo Imaging Systems for Cancer Investigations (R01)

NIH, NCI
Application deadline: 2013-02-05

This Funding Opportunity Announcement (FOA) issued by the Cancer Imaging and Radiation Research Programs of the National Cancer Institute (NCI), National Institutes of Health (NIH), encourages applications from research partnerships formed by academic and industrial investigators to accelerate the translation of either animal or human in vivo imaging, image guided, and/or spectroscopic systems and methods designed to solve targeted cancer problems for cancer research, clinical trials, and/or clinical practice. The partners on each application will establish an inter-disciplinary, multi-institutional research team to work in a strategic alliance to implement a coherent strategy to develop and translate the proposed system or methods with potential for significant impact on preclinical, single, or multisite clinical studies. Partnerships must include at least one lead academic and one lead industrial organization large or small among their numbers. For either preclinical or clinical research, funding may be requested for limited additional copies of prototype systems and methods in order to optimize and validate them across different platforms and/or research sites. Each partnership is encouraged to plan to solve its choice of targeted cancer problem within the five year funding period. This FOA supports clinical trials that emphasize optimization and validation of the performance of imaging systems, including devices, agents and/or methods. It will not support commercial production.

Past Due Grant Listing

NIH SHIFT Award: Small Businesses Helping Investigators to Fuel the Translation of Scientific Discoveries [SBIR: R43/R44]

NIH
Application deadline: 2010-04-05

Purpose. The primary objectives of the SHIFT SBIR initiative are: (1) to foster research that is translational in nature and (2) to transform academic scientific discoveries into commercial products and services. Academic researchers can be a driving force for new products and services in a small business concern (SBC). A major feature of the SHIFT program includes the requirement for an investigator who is primarily employed by a United States research institution at the time of application to transition to a small business concern (SBC) and be primarily employed (more than 50% time) by the SBC by or at the time of award. A SHIFT SBIR grant enables an SBC to increase both its scientific research staff and its core competencies. The Project Director/Principal Investigator (PD/PI) may also facilitate SBC licensing of intellectual property (IP) from the PD/PI’s prior academic institutions, promote collaboration opportunities with academic investigators, and enable better access to academic resources.

NIH NIGMS Minority Access to Research Careers (MARC) Ancillary Training Activities (T36)

NIH
Application deadline: 2010-04-07

Purpose. The goal of the MARC Ancillary Training Activities Program is to provide support for the attendance and participation of individuals from underrepresented groups and/or faculty from minority serving institutions in program-related scientific conferences, short courses, or other well -defined ancillary training activities to provide knowledge, skills, and/or networking capabilities that empower participants to succeed in the pursuit of a biomedically related research careers.

NIH Recovery Act Limited Competition: The NIH Director’s ARRA Funded Pathfinder Award to Promote Diversity in the Scientific Workforce (DP4)

Application deadline: 2010-05-04
LOI deadline: 2010-04-05

Purpose: The NIH recognizes a unique and compelling need to promote diversity in the biomedical, behavioral, clinical and social sciences research workforce. The NIH expects all of its efforts to diversify the workforce to lead to the recruitment of the most talented researchers from all groups; to improve the quality of the educational and training environment; to balance and broaden the perspective in setting research priorities; to improve the ability to recruit subjects from diverse backgrounds into clinical research protocols; and to improve the Nation’s capacity to address and eliminate health disparities. .This new FOA introduces a new research grant program to encourage exceptionally creative individual scientists to develop highly innovative and possibly transforming approaches for promoting diversity within the biomedical research workforce. To be considered highly innovative, the proposed research must reflect ideas substantially different from those already being pursued or it must apply existing research designs in new and innovative ways to unambiguously identify factors that will improve the retention of students, postdocs and faculty from diverse backgrounds. Awardees must commit a major portion (generally 30% or more) of their research effort to activities supported by the Director’s Pathfinder Award and the proposed research must be endorsed by the highest levels of institutional management.

Funding: NIH intends to commit approximately $10 million under this FOA. We anticipate that up to 5 awards will be made in fiscal year 2010, pending the number and quality of applications and availability of funds.

NIH (NIBIB, NIGMS, NIAMS) & NSF New Biomedical Frontiers at the Interface of the Life and Physical Sciences (R01)

NIH
Application deadline: 2010-05-18
LOI deadline: 2010-04-18

Purpose. The goal of this funding opportunity announcement, issued by the National Institutes of Health and the National Science Foundation, is to encourage grant applications from institutions/organizations that propose discovery research that may create entirely new areas of biomedical investigation through bridging the physical and life/behavioral sciences.

NIH Transforming Biomedicine at the Interface of the Life and Physical Sciences (R01)

Application deadline: 2010-05-18
LOI deadline: 2010-04-18

Purpose. The goal of this funding opportunity announcement, issued by the National Institutes of Health and the National Science Foundation, is to stimulate quantitative and physical scientists to work with biomedical scientists to transform technological innovation and basic knowledge in the quantitative sciences into new or improved devices or systems for health care.

INTERNATIONAL NEUROSCIENCE FELLOWSHIP (F05)

NIH
Application deadline: 2010-08-16
LOI deadline: 2010-07-16

The goal of the International Neuroscience Fellowship (INF) is to advance the training of qualified foreign neuroscientists and clinicians at the early or mid-career level, by enhancing their basic, translational or clinical research skills in a research setting in the United States (U.S.). This program aims to strengthen the intellectual capital of neuroscience research in international institutions. Awardees are expected to pursue future independent and productive careers, which stimulate research in the neurosciences on a global scale.
Individuals may receive up to three years of support for research training at a basic, translational or clinical research facility within the U.S. (referred to as the U.S. sponsoring institution).
The F05 Research Strategy section may not exceed 6 pages, including tables, graphs, figures, diagrams, and charts.
The PD/PI is the individual Fellowship Applicant. Eligible individual applicants include non-immigrant foreign scientists at the early or mid-career level. The applicant must have a doctoral or equivalent degree, and an endorsement from their home institution, with a guaranteed appointment upon completion of the fellowship. Applicants must be proficient in English and must have a sponsor in the U.S. who is affiliated with an eligible U.S. organization. Preference will be given to applicants from low- to middle-income countries.

Science, Mathematics and Research for Transformation (SMART) Scholarship for Service Program (DoD)

Department of Defense, USA
Application deadline: 2010-12-01

The U.S. Department of Defense (DOD) is currently seeking scholarship applications from undergraduate and graduate students nationwide who are enrolled in science or technology programs for the prestigious Science, Mathematics and Research for Transformation (SMART) Scholarship for Service Program. SMART is an opportunity for students pursuing an undergraduate or graduate degree in Science, Technology, Engineering, and Mathematics (STEM) disciplines to receive a full scholarship and be employed upon degree completion at a DoD research facility. The DOD expects to award 300 scholarships this year worth a total of $45 million.

Scholarships awarded include a cash award of $25,000 to $41,000 a year, full tuition, required fees, health insurance allowance, and book allowance. The program is intended for citizens of the United States; students must be at least 18 years of age to be eligible for an award.

The SMART Program is administered by the American Society for Engineering Education (ASEE ) and the Naval Postgraduate School (NPS). For more information, or to apply online, please visit: http://smart.asee.org/. Applications must be received by December 1, 2010.

Indo-US Collaborative Program on Law-Cost Medical Devices (R03)

NIH (NIAID, NIBIB, NICHD)
Application deadline: 2011-01-26

Purpose. The purpose of this program is to encourage collaborative research and/or technology development between scientists and engineers in the United States and India. This FOA issued by National Institute of Biomedical Imaging and Bioengineering (NIBIB) (http://www.nibib.nih.gov) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (http://www.nichd.nih.gov), National Institutes of Health, encourages Small Research Grant (R03) applications for its program on the collaborative development of low-cost medical devices; the Republic of India and the United States of America are inviting collaborative research projects involving U.S. and Indian investigators to develop new, low cost, appropriate diagnostic and therapeutic medical technologies for low-resource settings.

Application Due Date(s): January 26, 2011, May 24, 2011, September 23, 2011, January 24, 2012, May 24, 2012, September 24, 2012, January 24, 2013, May 24, 2013, September 24, 2013

SHIFT Award: Small Businesses Helping Investigators to Fuel the Translation of Scientific Discoveries [SBIR: R43/R44]

NIH
Application deadline: 2011-04-05

http://grants.nih.gov/grants/guide/pa-files/PA-10-122.html

Purpose. The primary objectives of the SHIFT SBIR initiative are: (1) to foster research that is translational in nature and (2) to transform academic scientific discoveries into commercial products and services. Academic researchers can be a driving force for new products and services in a small business concern (SBC). A major feature of the SHIFT program includes the requirement for an investigator who is primarily employed by a United States research institution at the time of application to transition to a small business concern (SBC) and be primarily employed (more than 50% time) by the SBC by or at the time of award. A SHIFT SBIR grant enables an SBC to increase both its scientific research staff and its core competencies. The Project Director/Principal Investigator (PD/PI) may also facilitate SBC licensing of intellectual property (IP) from the PD/PI’s prior academic institutions, promote collaboration opportunities with academic investigators, and enable better access to academic resources.

Application Due Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm
AIDS Application Due Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm#AIDS.

Expiration Date: January 8, 2013

New Biomedical Frontiers at the Interface of the Life and Physical Sciences (R01)

NIH (NIBIB, NIGMS, NIAMS) & NSF
Application deadline: 2011-05-18
LOI deadline: 2011-04-18

http://grants.nih.gov/grants/guide/pa-files/PAR-10-142.html

Research objectives

A number of innovative techniques and discoveries developed in the physical, computational and engineering sciences have resulted in tremendous breakthroughs in the biological and life sciences. In many cases, important biomedical problems could not have been solved without the critical involvement of engineers and physicists, such as the development of new imaging technologies, nanotechnology, and high throughput screening technologies. It is the intermingling of approaches from one area, applied to problems of another, that makes research at the intersection of the life and physical sciences so rich and full of opportunities (Research at the Intersection of the Physical and Life Sciences, National Research Council, National Academies, November 2009). The purpose of this initiative is to provide support for cutting-edge, visionary research, only possible through bridging the sciences, with the goal of setting the stage for the next biomedical breakthrough.

The National Institutes of Health and the National Science Foundation are issuing this joint announcement to encourage grant applications from institutions/organizations that propose discovery research that may create entirely new areas of biomedical investigation through bridging the physical and life/behavioral sciences. Appropriate topics include, but are not limited to those listed below:

  • self-healing/replicating nanodevices
  • biological computing
  • biologically-inspired next generation materials
  • biological power sources
  • non-invasive identification of disease
  • modeling and real-time observation of biomolecular and pharmacologic interactions: in vivo, in vitro, in silico
  • theoretical models of intercellular processes and robust methods for manipulation
  • accurate prediction of electrostatic interactions, solvent effects in aqueous biological systems, and trajectories of reactions
  • adapt complex methodologies, such as dynamical systems analysis, agent based modeling, discrete event simulation, and network analysis to problems such as quorum sensing, interconnected networks of cellular regulatory pathways, signal transduction, and social interactions and behavior change

NIBIB, NIGMS and NSF will consider a broad spectrum of research at the interface of the life and physical sciences, consistent with their missions. To be considered for funding by the NIAMS, applications must align with its mission of reducing the burden of arthritis and musculoskeletal and skin diseases. Applications most appropriate for NIAMS funding will propose research in basic biology, translational study and diseases of the muscles, skin, joints and bone. These applications should have the potential of advancing our understanding of diseases or improving human conditions or leading to prevention or novel therapies of diseases in NIAMS mission.

This initiative is forward-looking, so biomedical translation of the research need not be apparent at the time of application. Awards will be based on the degree of innovation and extent of potential paradigm shift – whether in an existing area or in the creation of an entirely new one. Approaches to overcome exceedingly difficult technical problems, even where prior attempts have failed, are welcome if the proposed technology or approach offers revolutionary new capabilities. This announcement supports a broad range of high-risk, biomedical research that can only be accomplished by bridging the physical, computational or engineering with the life and/or behavioral sciences. It is expected that there will be meaningful intellectual and project leadership contributions from multiple disciplines, so applications are strongly encouraged with multiple PIs that represent the physical, computational or engineering, and life and/or behavioral sciences. As this initiative is meant to underpin innovative new approaches, New Investigators that can contribute highly inventive perspectives are encouraged to apply. This bridging research should focus on developing enabling capabilities that can have future biomedical impact, and not on the immediate needs. Funded projects are expected to catalyze and generate new approaches and fields of biomedical study that can only emerge from the interface of the sciences.

Letters of Intent Receipt Date(s): April 18, 2010; April 18, 2011; April 18, 2012
NOTE: On-time submission requires that applications be successfully submitted to Grants.gov no later than 5:00 p.m. local time (of the applicant institution/organization).
Application Due Date(s): May 18, 2010; May 18, 2011; May 18, 2012

Transforming Biomedicine at the Interface of the Life and Physical Sciences (R01)

NIH (NIBIB, NIGMS, NIAMS)
Application deadline: 2011-05-18
LOI deadline: 2011-04-18

http://grants.nih.gov/grants/guide/pa-files/PAR-10-141.html

The National Institutes of Health and the National Science Foundation are issuing this joint announcement to encourage grant applications from institutions/organizations to encourage quantitative/physical scientists and engineers to apply their unique skills and perspectives to overcome important problems in translational research and catalyze clinical advances.

Some of the most significant biomedical advances in recent decades have emerged from the interface of the life and physical sciences, such as MR imaging, multifunctional biomarkers, drug-eluting stents, orthopedic devices, cochlear implants, pacemakers, high-throughput screening, cell-based therapies, and minimally-invasive procedures. Such advances have had a profound impact on health and the quality of life, and were driven by critical collaborations with scientists trained in the physical and quantitative fields. It is the intermingling of approaches from one area, applied to problems of another, that makes research at the intersection of the life and physical sciences so rich and full of opportunities (Research at the Intersection of the Physical and Life Sciences, National Research Council, National Academies, November 2009). Scientific contributions involving advanced computation and mathematics, optics, automation, process control, chemical and material engineering, optimization, and microelectronics are just a few of the disciplines and research areas that have underpinned many biomedical advances. This announcement encourages investigators from these disciplines and other research areas to partner with clinical researchers to translate promising laboratory concepts into the clinic.

Projects must propose an innovative application of the physical or quantitative sciences to help solve a translational or clinical problem. The application must highlight why a bridging approach is necessary and how this will lead to clinical implementation. It is strongly recommended that the project have at least one PD/PI from the physical or quantitative sciences, and at least one PD/PI from the clinical/biomedical sciences. To help ensure ultimate clinical utility, it is also recommended that these projects involve a commercial partner. Their role can vary from consultancy, active engagement in project design, to a substantial investment of project resources. It is expected that projects with greater or increasing levels of commercial involvement are more likely to achieve successful translation.

Illustrative examples of potential topics include, but are not limited to:

  • Deep Imaging Technologies – Develop whole-tissue, three-dimensional imaging with sub-micron resolution for studying tissue and cellular connectivity, metabolism and dynamics.
  • Develop computational models and/or informatics tools to analyze connectivity of cellular regulatory pathways, signal transduction pathways, and other biological processes.
  • Health Cyberinfrastructure – Adapt and create technologies for data integration, sharing and mining across disparate platforms for research, clinical decision support, and electronic health records.
  • Development of Biomarkers and Related Platform Technologies & Methods for Drug Discovery, Delivery and Response – Leverage ongoing efforts to develop and validate molecular biomarkers for many conditions, stimulate radically new platform technologies for data collection, and develop computational models to simulate biomarker response to therapy.
  • Quantitative and Personalized Image-Guided Interventions (IGI) – Integrate the fields of IGI and molecular biology to develop personalized IGI with tailored applications for the treatment of cancer, cardiovascular and neurological diseases. Develop computational strategies to radiation treatment that can be individualized and to minimize unnecessary radiation exposure.
  • Improved Biomaterials – Develop biomaterials that integrate with tissue to form chronically-stable capsule-free biotic-abiotic interfaces; complex scaffold materials to promote 3-dimensional tissue regeneration.

NIBIB, NIGMS and NSF will consider a broad spectrum of research at the interface of the life and physical sciences, consistent with their missions. To be considered for funding by the NIAMS, applications must align with its mission of reducing the burden of arthritis and musculoskeletal and skin diseases. Applications most appropriate for NIAMS funding will propose research in basic biology, translational study and diseases of the muscles, skin, joints and bone. These applications should have the potential of advancing our understanding of diseases or improving human conditions or leading to prevention or novel therapies of diseases in NIAMS mission.

Letters of Intent Receipt Date(s): April 18, 2010; April 18, 2011; April 18, 2012
NOTE: On-time submission requires that applications be successfully submitted to Grants.gov no later than 5:00 p.m. local time (of the applicant institution/organization).
Application Due Date(s): May 18, 2010; May 18, 2011; May 18, 2012

Indo-US Collaborative Program on Low-Cost Medical Devices (R03)

NIH (NIAID, NIBIB, NICHD)
Application deadline: 2011-05-24

Purpose. The purpose of this program is to encourage collaborative research and/or technology development between scientists and engineers in the United States and India. This FOA issued by National Institute of Biomedical Imaging and Bioengineering (NIBIB) (http://www.nibib.nih.gov) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (http://www.nichd.nih.gov), National Institutes of Health, encourages Small Research Grant (R03) applications for its program on the collaborative development of low-cost medical devices; the Republic of India and the United States of America are inviting collaborative research projects involving U.S. and Indian investigators to develop new, low cost, appropriate diagnostic and therapeutic medical technologies for low-resource settings.

Application Due Date(s): January 26, 2011, May 24, 2011, September 23, 2011, January 24, 2012, May 24, 2012, September 24, 2012, January 24, 2013, May 24, 2013, September 24, 2013

2011 NIDA Avant-Garde Award Program for HIV/AIDS Research (DP1)

NIH
Application deadline: 2011-05-26

TOTAL FUNDING AMOUNT: Awards will be for $500,000 in direct costs each year for five years
KEY RESEARCH AREAS: The NIDA Avant-Garde Award Program for HIV/AIDS Research is meant to complement NIDA’s traditional investigator-initiated grant programs by supporting individual scientists of exceptional creativity who propose high-impact research that will open new avenues for prevention and treatment of HIV/AIDS among drug abusers. The term “avant-garde” is used to describe highly innovative approaches that have the potential to be transformative— open new areas of research or lead to new avenues of treatment and prevention for HIV/AIDS among drug abusers. The proposed research should reflect ideas substantially different from those already being pursued by the investigator or others. The research proposed must be in an area described in the Trans – NIH Plan for HIV- Related Research http://www.oar.nih.gov/strategicplan/fy2011/index.asp.

SHIFT Award: Small Businesses Helping Investigators to Fuel the Translation of Scientific Discoveries [SBIR: R43/R44]

NIH
Application deadline: 2011-08-05

http://grants.nih.gov/grants/guide/pa-files/PA-10-122.html

Purpose. The primary objectives of the SHIFT SBIR initiative are: (1) to foster research that is translational in nature and (2) to transform academic scientific discoveries into commercial products and services. Academic researchers can be a driving force for new products and services in a small business concern (SBC). A major feature of the SHIFT program includes the requirement for an investigator who is primarily employed by a United States research institution at the time of application to transition to a small business concern (SBC) and be primarily employed (more than 50% time) by the SBC by or at the time of award. A SHIFT SBIR grant enables an SBC to increase both its scientific research staff and its core competencies. The Project Director/Principal Investigator (PD/PI) may also facilitate SBC licensing of intellectual property (IP) from the PD/PI’s prior academic institutions, promote collaboration opportunities with academic investigators, and enable better access to academic resources.

Application Due Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm
AIDS Application Due Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm#AIDS.

Expiration Date: January 8, 2013

Biophotonics

NSF
Application deadline: 2011-09-15

Biophotonics applies photonics technology to the fields of medicine, biology and biotechnology. Basic research and innovation in photonics that is very fundamental in science and engineering is needed to lay the foundation for new technologies beyond those that are mature and ready for application in medical diagnostics and therapies. Advances are needed in nanophotonics, optogenetics, contrast and targeting agents, ultra-thin probes, wide field imaging, and rapid biomarker screening. Low cost and minimally invasive medical diagnostics and therapies are key goals.

Indo-US Collaborative Program on Law-Cost Medical Devices (R03)

NIH (NIAID, NIBIB, NICHD)
Application deadline: 2011-09-23

Purpose. The purpose of this program is to encourage collaborative research and/or technology development between scientists and engineers in the United States and India. This FOA issued by National Institute of Biomedical Imaging and Bioengineering (NIBIB) (http://www.nibib.nih.gov) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (http://www.nichd.nih.gov), National Institutes of Health, encourages Small Research Grant (R03) applications for its program on the collaborative development of low-cost medical devices; the Republic of India and the United States of America are inviting collaborative research projects involving U.S. and Indian investigators to develop new, low cost, appropriate diagnostic and therapeutic medical technologies for low-resource settings.

Application Due Date(s): January 26, 2011, May 24, 2011, September 23, 2011, January 24, 2012, May 24, 2012, September 24, 2012, January 24, 2013, May 24, 2013, September 24, 2013

DOD Rapid Innovation Fund

DOD
Application deadline: 2011-10-31

KEY RESEARCH AREAS: The RIF program was established to facilitate the rapid insertion of innovative technologies into military systems or programs that meet critical national security needs, such as those supporting the resolution of … more »operational challenges characterized by Joint Urgent Operational Needs (JUONs). The RIF program also intends to facilitate innovative technologies that show a clear transition path to fielding the technology into existing Acquisition Category (ACAT) programs or other defense acquisition programs. The goals of the RIF reflect DOD’s emphasis on rapid, responsive acquisition and the engagement of small, innovative businesses in solving defense needs. The department’s goals for the RIF are to transition teh following: 1. Innovative technology, primarily from small businesses (including SBIR Phase II projects), that resolve operational challenges characterized by JUONs or other critical national security needs. 2. Innovative technology, primarily from small businesses (including SBIR Phase II projects), into existing Acquisition Category (ACAT) I- IA, II, III, IV programs, or into other defense acquisition programs. 3. DOD-reimbursed Independent Research and Development (IR&D) technology developed by defense industrial base tier 2 and 3 suppliers that resolve operational challenges characterized by JUONs or other critical national security needs. 4. DOD-reimbursed IR&D projects developed by defense industrial base tier 2 and 3 suppliers into existing ACAT I-IA, II, III, IV programs, or into other defense acquisition programs.

US-India Institutional Partnership Grant

United States-India Educational Foundation
Application deadline: 2011-11-01

TOTAL FUNDING AMOUNT: $250,000
KEY RESEARCH AREAS: Encouraging mutual understanding, facilitating educational reform, fostering economic development, and engaging civil society
ELIGIBILITY: Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD/PI) is invited to work with his/her organization to develop an application for support.

SHIFT Award: Small Businesses Helping Investigators to Fuel the Translation of Scientific Discoveries [SBIR: R43/R44]

NIH
Application deadline: 2011-12-05

http://grants.nih.gov/grants/guide/pa-files/PA-10-122.html

Purpose. The primary objectives of the SHIFT SBIR initiative are: (1) to foster research that is translational in nature and (2) to transform academic scientific discoveries into commercial products and services. Academic researchers can be a driving force for new products and services in a small business concern (SBC). A major feature of the SHIFT program includes the requirement for an investigator who is primarily employed by a United States research institution at the time of application to transition to a small business concern (SBC) and be primarily employed (more than 50% time) by the SBC by or at the time of award. A SHIFT SBIR grant enables an SBC to increase both its scientific research staff and its core competencies. The Project Director/Principal Investigator (PD/PI) may also facilitate SBC licensing of intellectual property (IP) from the PD/PI’s prior academic institutions, promote collaboration opportunities with academic investigators, and enable better access to academic resources.

Application Due Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm
AIDS Application Due Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm#AIDS.

Expiration Date: January 8, 2013

NIH Director's Transformative Research Awards (R01)

NIH
Application deadline: 2012-01-12

TOTAL FUNDING AMOUNT: No budget limit; $25M committed for program; up to 1/3 of funds will be reserved for projects requesting $1M per year; award duration is up to 5 years
KEY RESEARCH AREAS: The NIH Director’s Transformative Research Awards complements NIH’s traditional, investigator-initiated grant programs by supporting individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original and/or unconventional research with the potential to create new scientific paradigms. Little or no preliminary data are expected. Projects must clearly demonstrate potential to produce a major impact in a broad area of biomedical or behavioral research.

NSF Major Research Instrumentation (MRI)

NSF
Application deadline: 2012-01-26

TOTAL FUNDING AMOUNT: $100,000-$4 million for most disciplines; less than $100,000 – $4 million for social, behavioral and economic sciences.
KEY RESEARCH AREAS: Acquisition or development of shared research instrumentation
ELIGIBILITY: Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD/PI) is invited to work with his/her organization to develop an application for support.

Academic-Industrial Partnerships for Translation of in vivo Imaging Systems for Cancer Investigations (R01)

NIH, NCI
Application deadline: 2012-02-05

This Funding Opportunity Announcement (FOA) issued by the Cancer Imaging and Radiation Research Programs of the National Cancer Institute (NCI), National Institutes of Health (NIH), encourages applications from research partnerships formed by academic and industrial investigators to accelerate the translation of either animal or human in vivo imaging, image guided, and/or spectroscopic systems and methods designed to solve targeted cancer problems for cancer research, clinical trials, and/or clinical practice. The partners on each application will establish an inter-disciplinary, multi-institutional research team to work in a strategic alliance to implement a coherent strategy to develop and translate the proposed system or methods with potential for significant impact on preclinical, single, or multisite clinical studies. Partnerships must include at least one lead academic and one lead industrial organization large or small among their numbers. For either preclinical or clinical research, funding may be requested for limited additional copies of prototype systems and methods in order to optimize and validate them across different platforms and/or research sites. Each partnership is encouraged to plan to solve its choice of targeted cancer problem within the five year funding period. This FOA supports clinical trials that emphasize optimization and validation of the performance of imaging systems, including devices, agents and/or methods. It will not support commercial production.

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